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Gene expression of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex of the spontaneously hypertensive rat (SHR)

机译：突触体相关蛋白25（sNap-25）在自发性高血压大鼠（sHR）前额叶皮质中的基因表达

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Dopamine is believed to play an important role in the etiology of attention-deficit/hyperactivity disorder (ADHD). In our previous study, we showed that gene expression of dopamine D4 receptor decreased in the spontaneously hypertensive rat (SHR) in the prefrontal cortex (PFC). In the present study, we explored the potential causes of dysfunction in the dopamine system in ADHD. It is the first time that neuronal activities in both juvenile SHR and WKY rats have been measured by functional MRI (fMRI). Our results showed that in PFC the Blood Oxygenation Level Dependent (BOLD) signal response in SHR was much higher than WKY under stressful situations. We tested the effects of acute and repeated administration of amphetamine on behavioral changes in SHR combined with the expression of the neuronal activity marker, c-fos, in the PFC. Meanwhile dopamine-related gene expression was measured in the PFC after repeated administration of amphetamine. We found that potential neuronal damage occurred through deficit of D2-like receptor protective functions in the PFC of the SHR. We also measured the expression of synaptosomal-associated protein 25 (SNAP-25) in SHR in PFC. The results showed decreased expression of SNAP-25 mRNA in the PFC of SHR; this defect disappeared after repeated injection of D-AMP.
机译：多巴胺被认为在注意力缺陷/多动症（ADHD）的病因中起重要作用。在我们先前的研究中，我们显示了在额叶前皮质（PFC）的自发性高血压大鼠（SHR）中多巴胺D4受体的基因表达下降。在本研究中，我们探讨了多动症多巴胺系统功能障碍的潜在原因。这是首次通过功能性MRI（fMRI）测量了SHR和WKY幼年大鼠的神经元活动。我们的研究结果表明，在压力状态下，PFC中SHR的血氧依赖水平（BOLD）信号响应远高于WKY。我们测试了急性和反复给予苯丙胺对SHR行为变化的影响，并结合了PFC中神经元活性标记c-fos的表达。同时，在重复给予苯丙胺后，在PFC中测量多巴胺相关基因的表达。我们发现潜在的神经元损伤是通过SHR的PFC中D2样受体保护功能的缺失而发生的。我们还测量了SFC中PFC中突触体相关蛋白25（SNAP-25）的表达。结果显示SNHR-25 mRNA在SHR的PFC中表达减少；重复注射D-AMP后，该缺陷消失了。

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